ANCIENT societies conceived cure, disease, and death differently from modern societies. ANCIENT therapists often attributed diseases, pains, and deaths to supernatural causes, and thus, their cures were based on talisman, magic, spells, and supernatural forces. ANCIENT medicine also assigned a metaphysical origin to diseases in the first place, and a major part of their treatments were based on beliefs. In the ANCIENT GREEK thought, disease might arise from avenges of gods or as a result of their sufferings or a violation of a sacred taboo. Religious significance and myths of disease, death, and cure in ANCIENT Persia also imply their ontological position. According to ANCIENT Persians, Ahriman corrupted the world with evils and diseases. Creations of Ahriman find a place in human bodies, showing themselves as diseases. For them, medicine had an origin in Ahura. Thus, they make recourses to particular supplications (mantras) for healing and treatments. In this paper, I study diseases and healings from the perspective of ANCIENT Persians and GREEKs.